PRDX1

Entrez Summary: N/A
UniProt Summary: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-4.74
Olaparib 4μM R08 exp512	-4.38
Menadione 5μM R06 exp292	-4.21
Cryptotanshinone 12μM R05 exp227	-3.77
Rucaparib 6.5μM R08 exp520	-3.74
Nifuroxazide 5μM R03 exp102	-3.53
YM155 0.001μM R08 exp432	-3.34
Nifuroxazide 1μM R01 exp51	-2.77
UM0131023 0.05μM R05 exp248	-2.15
Celastrol 0.12μM R05 exp225	-1.89
Talazoparib 0.006μM R06 exp299	-1.83
Deguelin 0.15μM R05 exp209	-1.81
A-395N 10μM R05 exp219	-1.76
Ribavirin 10 to 15μM on day4 R04 exp160	-1.75
Tanespimycin 14μM R08 exp527	-1.72
Dynasore 7μM R08 exp436	1.72
BI-6727 0.0125μM R03 exp97	1.82
Thimerosal 0.85μM R08 exp529	2.15
Tubacin 1.6μM R07 exp416	2.75

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thioredoxin peroxidase activity
removal of superoxide radicals
cellular response to oxygen radical
cellular response to superoxide
response to superoxide
response to oxygen radical
natural killer cell mediated cytotoxicity
hydrogen peroxide catabolic process
natural killer cell mediated immunity
peroxidase activity
hydrogen peroxide metabolic process
superoxide metabolic process
leukocyte mediated cytotoxicity
antibiotic catabolic process
natural killer cell activation
cofactor catabolic process
retina homeostasis
cell redox homeostasis
cell killing
erythrocyte homeostasis
cellular oxidant detoxification
cellular detoxification
melanosome
antibiotic metabolic process
myeloid cell homeostasis
regulation of NIK/NF-kappaB signaling
reactive oxygen species metabolic process
detoxification
cellular response to reactive oxygen species
drug catabolic process
tissue homeostasis
response to reactive oxygen species
homeostasis of number of cells
cellular response to toxic substance
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
cellular response to oxidative stress
lymphocyte mediated immunity
cadherin binding
multicellular organismal homeostasis