PREX1 [The Human Chemical-Genetic Interaction Map Project]

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======= PREX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PREX1
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57580|57580]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCU6|Q8TCU6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PREX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PREX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606905|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|DEP|
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rac guanyl-nucleotide exchange factor activity|
|actin filament polymerization|
|dendritic shaft|
|positive regulation of substrate adhesion-dependent cell spreading|
|superoxide metabolic process|
|actin polymerization or depolymerization|
|regulation of substrate adhesion-dependent cell spreading|
|Rho guanyl-nucleotide exchange factor activity|
|neutrophil chemotaxis|
|protein polymerization|
|granulocyte chemotaxis|
|neutrophil migration|
|granulocyte migration|
|phospholipid binding|
|reactive oxygen species metabolic process|
|positive regulation of cell-substrate adhesion|
|myeloid leukocyte migration|
|growth cone|
|T cell differentiation|
|regulation of Rho protein signal transduction|
|leukocyte chemotaxis|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cell chemotaxis|
|regulation of cell-substrate adhesion|
|regulation of protein polymerization|
|T cell activation|
|lymphocyte differentiation|
|actin filament organization|
|regulation of Ras protein signal transduction|
|regulation of actin filament organization|
|GTPase activator activity|
|regulation of cell morphogenesis involved in differentiation|
|leukocyte differentiation|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|enzyme binding|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|leukocyte migration|
|lymphocyte activation|
|regulation of actin filament-based process|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|hemopoiesis|
|actin filament-based process|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.83|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.71|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PREX1 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>