PREX1
Gene Information
- Official Symbol: PREX1
- Official Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 57580
- UniProt: Q8TCU6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PH |
| DEP |
| RhoGEF |
GO Terms
| Rac guanyl-nucleotide exchange factor activity |
| actin filament polymerization |
| dendritic shaft |
| positive regulation of substrate adhesion-dependent cell spreading |
| superoxide metabolic process |
| actin polymerization or depolymerization |
| regulation of substrate adhesion-dependent cell spreading |
| Rho guanyl-nucleotide exchange factor activity |
| neutrophil chemotaxis |
| protein polymerization |
| granulocyte chemotaxis |
| neutrophil migration |
| granulocyte migration |
| phospholipid binding |
| reactive oxygen species metabolic process |
| positive regulation of cell-substrate adhesion |
| myeloid leukocyte migration |
| growth cone |
| T cell differentiation |
| regulation of Rho protein signal transduction |
| leukocyte chemotaxis |
| regulation of dendrite development |
| positive regulation of cell morphogenesis involved in differentiation |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| cell chemotaxis |
| regulation of cell-substrate adhesion |
| regulation of protein polymerization |
| T cell activation |
| lymphocyte differentiation |
| actin filament organization |
| regulation of Ras protein signal transduction |
| regulation of actin filament organization |
| GTPase activator activity |
| regulation of cell morphogenesis involved in differentiation |
| leukocyte differentiation |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| enzyme binding |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| leukocyte migration |
| lymphocyte activation |
| regulation of actin filament-based process |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| hemopoiesis |
| actin filament-based process |
| myeloid leukocyte activation |
| hematopoietic or lymphoid organ development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| regulation of neuron differentiation |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of cell projection organization |
| positive regulation of hydrolase activity |
| regulation of neurogenesis |
| cellular protein-containing complex assembly |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| cell activation |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| regulation of organelle organization |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of programmed cell death |
| neurogenesis |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| KU-0063794 3.8μM R02 exp71 | -1.83 |
| Dexamethasone 0.006 to 0.015μM on day4 R07 exp352 | -1.71 |
| Citral 75μM R06 exp275 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11003
- Expression level (log2 read counts): 6.05
Expression Distribution
PREX1 Expression in NALM6 Cells: 6.05
