PRG3 [The Human Chemical-Genetic Interaction Map Project]

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======= PRG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRG3
  * **<color #00a2e8>Official Name</color>**: proteoglycan 3, pro eosinophil major basic protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10394|10394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Y8|Q9Y2Y8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606814|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269|PubMed:10318872}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histamine biosynthetic process|
|basophil activation|
|histamine metabolic process|
|positive regulation of interleukin-8 biosynthetic process|
|imidazole-containing compound metabolic process|
|superoxide anion generation|
|extracellular matrix structural constituent conferring compression resistance|
|regulation of interleukin-8 biosynthetic process|
|leukotriene biosynthetic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|leukotriene metabolic process|
|superoxide metabolic process|
|neurotransmitter biosynthetic process|
|icosanoid biosynthetic process|
|positive regulation of interleukin-8 production|
|tertiary granule lumen|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|specific granule lumen|
|amine metabolic process|
|positive regulation of cytokine biosynthetic process|
|regulation of interleukin-8 production|
|neurotransmitter metabolic process|
|fatty acid derivative biosynthetic process|
|regulation of cytokine biosynthetic process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|fatty acid derivative metabolic process|
|carbohydrate binding|
|ammonium ion metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|regulation of neurotransmitter levels|
|regulation of translation|
|collagen-containing extracellular matrix|
|regulation of cellular amide metabolic process|
|positive regulation of cytokine production|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cytokine production|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16124
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRG3 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>