PRG3

Entrez Summary: N/A
UniProt Summary: Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269|PubMed:10318872}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histamine biosynthetic process
basophil activation
histamine metabolic process
positive regulation of interleukin-8 biosynthetic process
imidazole-containing compound metabolic process
superoxide anion generation
extracellular matrix structural constituent conferring compression resistance
regulation of interleukin-8 biosynthetic process
leukotriene biosynthetic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
leukotriene metabolic process
superoxide metabolic process
neurotransmitter biosynthetic process
icosanoid biosynthetic process
positive regulation of interleukin-8 production
tertiary granule lumen
cellular biogenic amine metabolic process
cellular amine metabolic process
specific granule lumen
amine metabolic process
positive regulation of cytokine biosynthetic process
regulation of interleukin-8 production
neurotransmitter metabolic process
fatty acid derivative biosynthetic process
regulation of cytokine biosynthetic process
icosanoid metabolic process
reactive oxygen species metabolic process
negative regulation of translation
negative regulation of cellular amide metabolic process
fatty acid derivative metabolic process
carbohydrate binding
ammonium ion metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
regulation of neurotransmitter levels
regulation of translation
collagen-containing extracellular matrix
regulation of cellular amide metabolic process
positive regulation of cytokine production