PRKAR1B

• Official Symbol: PRKAR1B
• Official Name: protein kinase cAMP-dependent type I regulatory subunit beta
• Aliases and Previous Symbols: N/A
• Entrez ID: 5575
• UniProt: P31321
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015].
• UniProt Summary: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:20819953}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 16154
• Expression level (log2 read counts): 3.77

Expression Distribution

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PRKAR1B Expression in NALM6 Cells: 3.77