PRKCDBP

Gene Information

Official Symbol: CAVIN3
Official Name: caveolae associated protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 112464
UniProt: Q969G5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13058
Expression level (log2 read counts): -6.6

Expression Distribution

negative regulation of fermentation
regulation of fermentation
cortical actin cytoskeleton organization
negative regulation of protein kinase B signaling
cortical cytoskeleton organization
protein kinase C binding
circadian regulation of gene expression
caveola
circadian rhythm
regulation of generation of precursor metabolites and energy
positive regulation of ERK1 and ERK2 cascade
regulation of protein kinase B signaling
rhythmic process
regulation of ERK1 and ERK2 cascade
actin cytoskeleton organization
negative regulation of intracellular signal transduction
positive regulation of MAPK cascade
actin filament-based process
protein-containing complex
regulation of MAPK cascade
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
cytoskeleton organization
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
negative regulation of response to stimulus
positive regulation of signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling