PRKRA [The Human Chemical-Genetic Interaction Map Project]

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======= PRKRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKRA
  * **<color #00a2e8>Official Name</color>**: protein activator of interferon induced protein kinase EIF2AK2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8575|8575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75569|O75569]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603424|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsrm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-miRNA binding|
|RISC-loading complex|
|outer ear morphogenesis|
|production of siRNA involved in RNA interference|
|pre-miRNA processing|
|RNA interference|
|middle ear morphogenesis|
|miRNA metabolic process|
|production of miRNAs involved in gene silencing by miRNA|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|enzyme activator activity|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|positive regulation of intrinsic apoptotic signaling pathway|
|double-stranded RNA binding|
|gene silencing by RNA|
|ear morphogenesis|
|gene silencing|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|protein stabilization|
|ear development|
|regulation of gene expression, epigenetic|
|skeletal system morphogenesis|
|cellular response to oxidative stress|
|sensory organ morphogenesis|
|response to virus|
|regulation of protein stability|
|embryonic organ morphogenesis|
|enzyme binding|
|ncRNA processing|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|embryonic organ development|
|ncRNA metabolic process|
|skeletal system development|
|posttranscriptional regulation of gene expression|
|sensory organ development|
|embryonic morphogenesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|protein homodimerization activity|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.73|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 181/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|1/28|
|bone|8/26|
|breast|9/33|
|central nervous system|18/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|19/75|
|lymphocyte|4/16|
|ovary|5/26|
|pancreas|11/24|
|peripheral nervous system|6/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|2/9|
|thyroid|2/2|
|upper aerodigestive|8/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKRA Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>