PRKRA

Official Symbol: PRKRA
Official Name: protein activator of interferon induced protein kinase EIF2AK2
Aliases and Previous Symbols: N/A
Entrez ID: 8575
UniProt: O75569
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
UniProt Summary: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 181/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	10/28
blood	1/28
bone	8/26
breast	9/33
central nervous system	18/56
cervix	2/4
colorectal	5/17
esophagus	5/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	2/20
lung	19/75
lymphocyte	4/16
ovary	5/26
pancreas	11/24
peripheral nervous system	6/16
plasma cell	1/15
prostate	0/1
skin	9/24
soft tissue	2/9
thyroid	2/2
upper aerodigestive	8/22
urinary tract	3/29
uterus	1/5

Expression Distribution

Screen	Score
Losmapimod 1μM R07 exp376	1.73
Prochlorperazine 5.2μM R02 exp77	1.75

pre-miRNA binding
RISC-loading complex
outer ear morphogenesis
production of siRNA involved in RNA interference
pre-miRNA processing
RNA interference
middle ear morphogenesis
miRNA metabolic process
production of miRNAs involved in gene silencing by miRNA
production of small RNA involved in gene silencing by RNA
dsRNA processing
enzyme activator activity
gene silencing by miRNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
positive regulation of intrinsic apoptotic signaling pathway
double-stranded RNA binding
gene silencing by RNA
ear morphogenesis
gene silencing
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
protein stabilization
ear development
regulation of gene expression, epigenetic
skeletal system morphogenesis
cellular response to oxidative stress
sensory organ morphogenesis
response to virus
regulation of protein stability
embryonic organ morphogenesis
enzyme binding
ncRNA processing
response to oxidative stress
regulation of apoptotic signaling pathway
embryonic organ development
ncRNA metabolic process
skeletal system development
posttranscriptional regulation of gene expression
sensory organ development