PRKRIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRKRIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKRIP1
  * **<color #00a2e8>Official Name</color>**: PRKR interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79706|79706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H875|Q9H875]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKRIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKRIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617458|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1168|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase inhibitor activity|
|double-stranded RNA binding|
|spliceosomal complex|
|renal system process|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|RNA splicing|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|protein kinase binding|
|mRNA processing|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mRNA metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-1.94|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.79|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.85|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.11|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.11|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.33|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pgm3|PGM3]]|0.422|
|[[:human genes:c:cxorf56|CXorf56]]|0.418|
|[[:human genes:t:tkt|TKT]]|0.412|
|[[:human genes:r:rpe|RPE]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 34/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|4/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2748
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKRIP1 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>