PRKRIP1

Entrez Summary: N/A
UniProt Summary: Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 34/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	0/26
breast	4/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	0/5

Expression Distribution

protein kinase inhibitor activity
double-stranded RNA binding
spliceosomal complex
renal system process
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
RNA splicing
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
mRNA processing
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
mRNA metabolic process
negative regulation of catalytic activity
regulation of protein kinase activity
nucleolus
regulation of kinase activity
RNA processing
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of protein phosphorylation
regulation of phosphorylation
RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
system process
gene expression