PRKRIR [The Human Chemical-Genetic Interaction Map Project]

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======= PRKRIR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THAP12
  * **<color #00a2e8>Official Name</color>**: THAP domain containing 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5612|5612]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43422|O43422]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKRIR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKRIR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607374|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dimer Tnp hAT|
|THAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein dimerization activity|
|negative regulation of cell population proliferation|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.7|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.77|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.79|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.82|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.84|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.87|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.91|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.05|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.06|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.06|
|[[:results:exp539|42°C R08 exp539]]|2.12|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.2|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.23|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.25|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.26|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.39|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.52|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.65|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|4.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:top3a|TOP3A]]|0.487|
|[[:human genes:b:bap1|BAP1]]|0.467|
|[[:human genes:h:hccs|HCCS]]|0.452|
|[[:human genes:d:dap3|DAP3]]|0.45|
|[[:human genes:h:hars|HARS]]|0.444|
|[[:human genes:o:opa1|OPA1]]|0.427|
|[[:human genes:t:tmem242|TMEM242]]|0.426|
|[[:human genes:d:dohh|DOHH]]|0.425|
|[[:human genes:r:rmi2|RMI2]]|0.424|
|[[:human genes:p:ppa2|PPA2]]|0.424|
|[[:human genes:a:actb|ACTB]]|0.42|
|[[:human genes:y:yars2|YARS2]]|0.419|
|[[:human genes:t:tp53|TP53]]|0.418|
|[[:human genes:c:casp9|CASP9]]|0.418|
|[[:human genes:r:rpusd4|RPUSD4]]|0.418|
|[[:human genes:m:mrpl23|MRPL23]]|0.417|
|[[:human genes:v:vars2|VARS2]]|0.414|
|[[:human genes:s:slc25a26|SLC25A26]]|0.414|
|[[:human genes:m:mrps14|MRPS14]]|0.413|
|[[:human genes:c:cycs|CYCS]]|0.412|
|[[:human genes:e:eny2|ENY2]]|0.407|
|[[:human genes:m:mrpl53|MRPL53]]|0.405|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.401|
|[[:human genes:t:trim28|TRIM28]]|0.401|
|[[:human genes:m:mrps5|MRPS5]]|0.401|
|[[:human genes:g:gfm1|GFM1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2143
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKRIR Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>