PRKRIR

Entrez Summary: N/A
UniProt Summary: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	1.7
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.77
Deferoxamine 11μM R07 exp350	1.79
CoCl2 18μM R07 exp346	1.82
Pimelic-diphenylamide-106 5μM R00 exp28	1.84
Benzoate 20000μM R08 exp456	1.87
5-Fluorouracil 20μM R00 exp2	1.91
PU-H71 1μM R08 exp515	2.05
AICAR 240μM R05 exp211	2.06
Mitomycin-C 0.06μM R08 exp503	2.06
42°C R08 exp539	2.12
CI-1040 9.5μM R08 exp472	2.2
Aminopterin 0.005μM R07 exp335	2.23
Actinomycin-D 0.001μM R00 exp3	2.25
GSK-J4 1.5μM R08 exp441	2.26
UM131593 0.2μM R03 exp106	2.39
Taxol 0.004μM R03 exp103	2.52
Olaparib 4μM R08 exp512	2.72
Nutlin-3A 1.6μM R06 exp294	3.65
Diepoxybutane 3μM R07 exp354	4.26

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/26
breast	0/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	2/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	0/5

Expression Distribution

Dimer Tnp hAT
THAP

protein dimerization activity
negative regulation of cell population proliferation
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation