PRL [The Human Chemical-Genetic Interaction Map Project]

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======= PRL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRL
  * **<color #00a2e8>Official Name</color>**: prolactin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5617|5617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01236|P01236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Prolactin acts primarily on the mammary gland by promoting lactation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prolactin receptor binding|
|positive regulation of lactation|
|regulation of lactation|
|growth hormone receptor signaling pathway via JAK-STAT|
|endosome lumen|
|growth hormone receptor signaling pathway|
|cellular response to growth hormone stimulus|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|response to growth hormone|
|negative regulation of endothelial cell proliferation|
|regulation of pri-miRNA transcription by RNA polymerase II|
|lactation|
|regulation of multicellular organism growth|
|body fluid secretion|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|hormone activity|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|mammary gland development|
|regulation of endothelial cell proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|female pregnancy|
|multi-multicellular organism process|
|cellular response to peptide hormone stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|cellular response to peptide|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|response to peptide hormone|
|gland development|
|positive regulation of secretion|
|response to peptide|
|regulation of body fluid levels|
|response to nutrient levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of growth|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion|
|response to hormone|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|secretion|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRL Expression in NALM6 Cells: -1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>