PRL

Entrez Summary: This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].
UniProt Summary: Prolactin acts primarily on the mammary gland by promoting lactation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prolactin receptor binding
positive regulation of lactation
regulation of lactation
growth hormone receptor signaling pathway via JAK-STAT
endosome lumen
growth hormone receptor signaling pathway
cellular response to growth hormone stimulus
positive regulation of pri-miRNA transcription by RNA polymerase II
response to growth hormone
negative regulation of endothelial cell proliferation
regulation of pri-miRNA transcription by RNA polymerase II
lactation
regulation of multicellular organism growth
body fluid secretion
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
hormone activity
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
negative regulation of epithelial cell proliferation
mammary gland development
regulation of endothelial cell proliferation
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
female pregnancy
multi-multicellular organism process
cellular response to peptide hormone stimulus
regulation of angiogenesis
regulation of vasculature development
cellular response to peptide
regulation of developmental growth
regulation of epithelial cell proliferation
response to peptide hormone
gland development
positive regulation of secretion
response to peptide
regulation of body fluid levels
response to nutrient levels
transmembrane receptor protein tyrosine kinase signaling pathway