PRLH

Entrez Summary: N/A
UniProt Summary: Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
WYE-354 6μM R02 exp90	1.77
Salinomycin 3.5μM R08 exp521	1.89

prolactin-releasing peptide receptor binding
reduction of food intake in response to dietary excess
response to dietary excess
neuropeptide hormone activity
eating behavior
autonomic nervous system development
energy reserve metabolic process
regulation of multicellular organism growth
feeding behavior
hormone activity
fat cell differentiation
response to glucose
response to hexose
response to monosaccharide
response to carbohydrate
tissue homeostasis
response to insulin
energy derivation by oxidation of organic compounds
multicellular organismal homeostasis
regulation of developmental growth
anatomical structure homeostasis
response to peptide hormone
generation of precursor metabolites and energy
response to peptide
response to nutrient levels
response to extracellular stimulus
behavior
regulation of growth
response to hormone
oxidation-reduction process
response to organonitrogen compound
response to nitrogen compound
lipid metabolic process
G protein-coupled receptor signaling pathway
response to endogenous stimulus
response to oxygen-containing compound
homeostatic process
extracellular region