PRMT1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRMT1
  * **<color #00a2e8>Official Name</color>**: protein arginine methyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3276|3276]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99873|Q99873]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602950|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 11|
|Methyltransf 18|
|PrmA|
|PRMT5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-methyltransferase activity|
|positive regulation of hemoglobin biosynthetic process|
|histone methyltransferase activity (H4-R3 specific)|
|regulation of hemoglobin biosynthetic process|
|protein-arginine omega-N monomethyltransferase activity|
|negative regulation of megakaryocyte differentiation|
|mitogen-activated protein kinase p38 binding|
|histone H4-R3 methylation|
|protein-arginine N-methyltransferase activity|
|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|
|protein-arginine omega-N asymmetric methyltransferase activity|
|histone-arginine N-methyltransferase activity|
|protein methyltransferase activity|
|S-adenosyl-L-methionine binding|
|peptidyl-arginine omega-N-methylation|
|peptidyl-arginine N-methylation|
|histone methyltransferase activity|
|methylosome|
|histone arginine methylation|
|peptidyl-arginine methylation|
|methyl-CpG binding|
|peptidyl-arginine modification|
|positive regulation of p38MAPK cascade|
|positive regulation of erythrocyte differentiation|
|regulation of p38MAPK cascade|
|regulation of erythrocyte differentiation|
|methyltransferase activity|
|regulation of megakaryocyte differentiation|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|negative regulation of myeloid cell differentiation|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|positive regulation of myeloid cell differentiation|
|histone methylation|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|protein alkylation|
|protein methylation|
|negative regulation of hemopoiesis|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of hemopoiesis|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|regulation of myeloid cell differentiation|
|negative regulation of cell cycle phase transition|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|macromolecule methylation|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|methylation|
|negative regulation of cell cycle process|
|protein homooligomerization|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|in utero embryonic development|
|regulation of mitotic cell cycle phase transition|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|protein complex oligomerization|
|positive regulation of MAPK cascade|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|mitotic cell cycle|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|neuron development|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|cell cycle process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chromosome organization|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|cell cycle|
|positive regulation of developmental process|
|RNA binding|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.65|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.34|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.98|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.92|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.91|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.83|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.78|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.78|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 688/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|20/21|
|liver|20/20|
|lung|67/75|
|lymphocyte|14/14|
|ovary|22/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 418
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRMT1 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>