PRMT2
Gene Information
- Official Symbol: PRMT2
- Official Name: protein arginine methyltransferase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3275
- UniProt: P55345
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| PRMT5 |
| PrmA |
| SH3 1 |
| MTS |
| Methyltransf 18 |
GO Terms
| progesterone receptor binding |
| protein-arginine N-methyltransferase activity |
| protein-arginine omega-N asymmetric methyltransferase activity |
| peptidyl-arginine methylation, to asymmetrical-dimethyl arginine |
| histone-arginine N-methyltransferase activity |
| peptidyl-arginine omega-N-methylation |
| histone methyltransferase activity |
| peptidyl-arginine N-methylation |
| peroxisome proliferator activated receptor binding |
| retinoic acid receptor binding |
| histone arginine methylation |
| peptidyl-arginine methylation |
| regulation of androgen receptor signaling pathway |
| peptidyl-arginine modification |
| thyroid hormone receptor binding |
| estrogen receptor binding |
| androgen receptor binding |
| regulation of intracellular steroid hormone receptor signaling pathway |
| negative regulation of NF-kappaB transcription factor activity |
| developmental cell growth |
| cell growth |
| histone methylation |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of cell cycle G1/S phase transition |
| protein methylation |
| protein alkylation |
| regulation of G1/S transition of mitotic cell cycle |
| negative regulation of DNA-binding transcription factor activity |
| regulation of cell cycle G1/S phase transition |
| negative regulation of mitotic cell cycle phase transition |
| negative regulation of cell cycle phase transition |
| macromolecule methylation |
| protein-containing complex binding |
| transcription coactivator activity |
| negative regulation of mitotic cell cycle |
| methylation |
| negative regulation of cell cycle process |
| histone modification |
| covalent chromatin modification |
| developmental growth |
| growth |
| regulation of mitotic cell cycle phase transition |
| regulation of DNA-binding transcription factor activity |
| regulation of cell cycle phase transition |
| negative regulation of cell cycle |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| chromatin organization |
| regulation of cell cycle process |
| nucleolus |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| chromosome organization |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5052
- Expression level (log2 read counts): 5.34
Expression Distribution
PRMT2 Expression in NALM6 Cells: 5.34
