PRMT8 [The Human Chemical-Genetic Interaction Map Project]

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======= PRMT8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRMT8
  * **<color #00a2e8>Official Name</color>**: protein arginine methyltransferase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56341|56341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR22|Q9NR22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRMT8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRMT8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610086|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRMT5|
|Methyltransf 18|
|PrmA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anchored component of the cytoplasmic side of the plasma membrane|
|protein-arginine omega-N monomethyltransferase activity|
|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|
|protein-arginine omega-N asymmetric methyltransferase activity|
|histone-arginine N-methyltransferase activity|
|peptidyl-arginine omega-N-methylation|
|S-adenosyl-L-methionine binding|
|peptidyl-arginine N-methylation|
|S-adenosylmethionine-dependent methyltransferase activity|
|histone arginine methylation|
|peptidyl-arginine methylation|
|peptidyl-arginine modification|
|histone methylation|
|protein alkylation|
|protein methylation|
|regulation of protein binding|
|macromolecule methylation|
|methylation|
|protein homooligomerization|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|protein heterodimerization activity|
|protein complex oligomerization|
|chromatin organization|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|chromosome organization|
|identical protein binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.74|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cope|COPE]]|0.463|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.455|
|[[:human genes:c:c14orf93|C14orf93]]|0.451|
|[[:human genes:s:snrpa1|SNRPA1]]|0.43|
|[[:human genes:c:ckap5|CKAP5]]|0.425|
|[[:human genes:p:pwp2|PWP2]]|0.418|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.407|
|[[:human genes:d:ddt|DDT]]|0.402|
|[[:human genes:o:orc1|ORC1]]|0.402|
|[[:human genes:t:tfip11|TFIP11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2392
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRMT8 Expression in NALM6 Cells: 0.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>