PRMT8

Entrez Summary: N/A
UniProt Summary: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anchored component of the cytoplasmic side of the plasma membrane
protein-arginine omega-N monomethyltransferase activity
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
protein-arginine omega-N asymmetric methyltransferase activity
histone-arginine N-methyltransferase activity
peptidyl-arginine omega-N-methylation
S-adenosyl-L-methionine binding
peptidyl-arginine N-methylation
S-adenosylmethionine-dependent methyltransferase activity
histone arginine methylation
peptidyl-arginine methylation
peptidyl-arginine modification
histone methylation
protein alkylation
protein methylation
regulation of protein binding
macromolecule methylation
methylation
protein homooligomerization
histone modification
covalent chromatin modification
regulation of binding
protein heterodimerization activity
protein complex oligomerization
chromatin organization
protein homodimerization activity
peptidyl-amino acid modification
chromosome organization
identical protein binding
protein-containing complex assembly
protein-containing complex subunit organization