PRND

Entrez Summary: N/A
UniProt Summary: Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530). {ECO:0000250|UniProtKB:Q9QUG3, ECO:0000269|PubMed:15218028, ECO:0000269|PubMed:20411530}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.002μM R01 exp60	-1.74
Sucrose 20000μM R06 exp298	1.78

Doppel
Prion

cellular copper ion homeostasis
copper ion homeostasis
anchored component of external side of plasma membrane
acrosome reaction
copper ion binding
cellular transition metal ion homeostasis
transition metal ion homeostasis
single fertilization
fertilization
protein homooligomerization
protein complex oligomerization
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
sexual reproduction
cellular homeostasis
multi-organism reproductive process
chemical homeostasis
reproductive process
reproduction
protein-containing complex assembly
homeostatic process
protein-containing complex subunit organization
extracellular region