PRODH2

Entrez Summary: N/A
UniProt Summary: Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. {ECO:0000269|PubMed:25697095}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

oxidoreductase activity, acting on the CH-NH group of donors
proline dehydrogenase activity
proline catabolic process to glutamate
proline catabolic process
glyoxylate metabolic process
proline metabolic process
glutamine family amino acid catabolic process
glutamate metabolic process
FAD binding
cellular aldehyde metabolic process
glutamine family amino acid metabolic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
mitochondrial inner membrane
heterocycle catabolic process
small molecule catabolic process
organic cyclic compound catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process