PRPF31 [The Human Chemical-Genetic Interaction Map Project]

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======= PRPF31 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRPF31
  * **<color #00a2e8>Official Name</color>**: pre-mRNA processing factor 31
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26121|26121]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWY3|Q8WWY3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRPF31&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRPF31|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606419|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. {ECO:0000269|PubMed:11867543}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NOSIC|
|Nop|
|Prp31 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNP binding|
|U4atac snRNP|
|U4atac snRNA binding|
|snoRNA localization|
|U4 snRNA binding|
|U2-type spliceosomal complex|
|U4 snRNP|
|spliceosomal tri-snRNP complex assembly|
|MLL1 complex|
|ribonucleoprotein complex binding|
|U4/U6 x U5 tri-snRNP complex|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|Cajal body|
|ribonucleoprotein complex localization|
|RNA localization|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.05|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.74|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.7|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.74|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.79|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.79|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.89|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.91|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.96|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.99|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.06|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.11|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.22|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.3|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.36|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.51|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.435|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 407
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRPF31 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>