PRPF31

Entrez Summary: This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009].
UniProt Summary: Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. {ECO:0000269|PubMed:11867543}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-2.05
DABN 20μM R00 exp17	-1.74
GSK461364A 0.1μM R03 exp126	-1.7
UM0131023 0.05μM R05 exp248	1.74
CHIR-124 0.04μM R06 exp272	1.79
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.79
Rifampicin 30μM R08 exp430	1.89
Cisplatin 0.35μM R06 exp273	1.91
HMS-I1 1μM R01 exp46	1.96
Dexamethasone 0.006μM R07 exp351	1.99
YM155 0.0002μM R01 exp61	2.06
UM0130462 0.025 to 0.035μM day4 R05 exp247	2.11
Taxol 0.002μM R01 exp54	2.22
Vinblastine 0.002μM R01 exp60	2.3
Pyridostatin 4μM R05 exp240	2.36
UMK57 1μM R01 exp59	2.51
BI-6727 0.001μM R01 exp42	2.83

Global Fraction of Cell Lines Where Essential: 726/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Gene	Correlation
RRM1	0.435
RUVBL2	0.428

snRNP binding
U4atac snRNP
U4atac snRNA binding
snoRNA localization
U4 snRNA binding
U2-type spliceosomal complex
U4 snRNP
spliceosomal tri-snRNP complex assembly
MLL1 complex
ribonucleoprotein complex binding
U4/U6 x U5 tri-snRNP complex
spliceosomal snRNP assembly
U2-type precatalytic spliceosome
Cajal body
ribonucleoprotein complex localization
RNA localization
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression