PRPF40A [The Human Chemical-Genetic Interaction Map Project]

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======= PRPF40A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRPF40A
  * **<color #00a2e8>Official Name</color>**: pre-mRNA processing factor 40 homolog A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55660|55660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75400|O75400]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRPF40A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRPF40A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|FF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type prespliceosome|
|proline-rich region binding|
|U1 snRNP|
|mRNA cis splicing, via spliceosome|
|regulation of cytokinesis|
|nuclear matrix|
|regulation of cell shape|
|regulation of cell division|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|regulation of cell morphogenesis|
|cell division|
|mRNA metabolic process|
|regulation of cell cycle process|
|RNA processing|
|cell migration|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|regulation of cell cycle|
|locomotion|
|cell cycle|
|RNA binding|
|movement of cell or subcellular component|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.03|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.82|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.84|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.89|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 355/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|6/28|
|bone|13/26|
|breast|21/33|
|central nervous system|23/56|
|cervix|4/4|
|colorectal|7/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|7/21|
|liver|5/20|
|lung|40/75|
|lymphocyte|8/16|
|ovary|15/26|
|pancreas|13/24|
|peripheral nervous system|7/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRPF40A Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>