PRPF40A

Entrez Summary: N/A
UniProt Summary: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 355/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	17/28
blood	6/28
bone	13/26
breast	21/33
central nervous system	23/56
cervix	4/4
colorectal	7/17
esophagus	8/13
fibroblast	0/1
gastric	8/16
kidney	7/21
liver	5/20
lung	40/75
lymphocyte	8/16
ovary	15/26
pancreas	13/24
peripheral nervous system	7/16
plasma cell	9/15
prostate	0/1
skin	10/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	17/22
urinary tract	14/29
uterus	1/5

Expression Distribution

U2-type prespliceosome
proline-rich region binding
U1 snRNP
mRNA cis splicing, via spliceosome
regulation of cytokinesis
nuclear matrix
regulation of cell shape
regulation of cell division
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
regulation of cell morphogenesis
cell division
mRNA metabolic process
regulation of cell cycle process
RNA processing
cell migration
regulation of anatomical structure morphogenesis
localization of cell
cell motility
cytoskeleton organization
regulation of cell cycle
locomotion
cell cycle
RNA binding
movement of cell or subcellular component
RNA metabolic process
membrane
gene expression