PRPF4 [The Human Chemical-Genetic Interaction Map Project]

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======= PRPF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRPF4
  * **<color #00a2e8>Official Name</color>**: pre-mRNA processing factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9128|9128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43172|O43172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRPF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRPF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607795|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. {ECO:0000269|PubMed:25383878}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|PRP4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal snRNP complex|
|U4/U6 snRNP|
|U4 snRNA binding|
|U6 snRNA binding|
|U4/U6 x U5 tri-snRNP complex|
|U2-type precatalytic spliceosome|
|Cajal body|
|spliceosomal complex|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.15|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.11|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.06|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.93|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.88|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.81|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.71|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.73|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.75|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.81|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.82|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.9|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.93|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.98|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.12|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.39|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.43|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:madcam1|MADCAM1]]|0.438|
|[[:human genes:a:atxn1|ATXN1]]|0.437|
|[[:human genes:k:kpnb1|KPNB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 408/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|18/28|
|bone|13/26|
|breast|16/33|
|central nervous system|25/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|10/21|
|liver|13/20|
|lung|41/75|
|lymphocyte|7/16|
|ovary|18/26|
|pancreas|17/24|
|peripheral nervous system|14/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|15/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRPF4 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>