PRPSAP2

Entrez Summary: N/A
UniProt Summary: Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ribose phosphate diphosphokinase activity
ribose phosphate diphosphokinase complex
5-phosphoribose 1-diphosphate metabolic process
5-phosphoribose 1-diphosphate biosynthetic process
enzyme inhibitor activity
nucleoside metabolic process
glycosyl compound metabolic process
purine nucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
bone development
magnesium ion binding
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
skeletal system development
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
negative regulation of catalytic activity
organophosphate metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
negative regulation of molecular function
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process