PRR5L

Gene Information

Official Symbol: PRR5L
Official Name: proline rich 5 like
Aliases and Previous Symbols: N/A
Entrez ID: 79899
UniProt: Q6MZQ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36- associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16873
Expression level (log2 read counts): -1.04

Expression Distribution

TORC2 signaling
TORC2 complex
TOR signaling
regulation of fibroblast migration
positive regulation of mRNA catabolic process
positive regulation of mRNA metabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of intracellular protein transport
regulation of mRNA catabolic process
positive regulation of intracellular transport
regulation of intracellular protein transport
cellular response to oxidative stress
ubiquitin protein ligase binding
positive regulation of cellular protein localization
regulation of mRNA metabolic process
regulation of intracellular transport
positive regulation of cellular catabolic process
response to oxidative stress
negative regulation of protein phosphorylation
positive regulation of protein transport
positive regulation of catabolic process
negative regulation of phosphorylation
positive regulation of establishment of protein localization
regulation of cellular protein localization
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of cellular catabolic process
regulation of cell migration
regulation of cell motility
regulation of cellular localization
regulation of locomotion
positive regulation of transport
regulation of cellular component movement
regulation of catabolic process
positive regulation of protein phosphorylation