PRRC1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRRC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRRC1
  * **<color #00a2e8>Official Name</color>**: proline rich coiled-coil 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=133619|133619]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96M27|Q96M27]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRRC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRRC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621301|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTPase I-T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of protein kinase A activity|
|protein kinase A regulatory subunit binding|
|activation of protein kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.49|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.32|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.1|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.03|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.76|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.71|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.71|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.76|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.77|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.78|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.86|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.88|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.9|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.92|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.99|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.01|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.11|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.12|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8796
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRRC1 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>