PRRC1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lapatinib 5μM R01 exp47	-2.49
Trametinib 10μM R02 exp83	-2.32
LB-100 2μM R05 exp210	-2.1
Golgicide-A 4μM R03 exp122	-2.03
Hydroxyurea 15μM R06 exp289	-1.76
Isoniazid 100μM R08 exp494	-1.71
SGC2043 10μM R03 exp152	-1.71
SGC0946 7μM R03 exp151	1.76
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.77
Cerivastatin 0.15μM R05 exp226	1.78
D-Fructose 10000μM R06 exp279	1.78
Glyphosate 1000μM R06 exp283	1.86
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.88
PU-H71 1μM R08 exp515	1.9
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.92
Tunicamycin 0.04μM R07 exp418	1.99
Doxorubicin 0.02μM R08 exp478	2.01
2-Methoxyestradiol 0.55μM R07 exp310	2.11
HMS-I2 10μM R06 exp288	2.12
Adefovir 20μM R07 exp332	2.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

activation of protein kinase A activity
protein kinase A regulatory subunit binding
activation of protein kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
Golgi apparatus
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process