PRSS37

Entrez Summary: N/A
UniProt Summary: Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891). {ECO:0000250|UniProtKB:Q9DAA4, ECO:0000269|PubMed:27649891}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-1.97
HMS-I2 5μM R06 exp287	1.88

positive regulation of acrosome reaction
positive regulation of fertilization
regulation of acrosome reaction
regulation of fertilization
binding of sperm to zona pellucida
sperm-egg recognition
regulation of protein processing
regulation of protein maturation
cell-cell recognition
positive regulation of reproductive process
acrosomal vesicle
secretory granule
single fertilization
regulation of reproductive process
serine-type endopeptidase activity
fertilization
protein maturation
cell recognition
positive regulation of multi-organism process
regulation of proteolysis
regulation of multi-organism process
sexual reproduction
cell migration
multi-organism reproductive process
localization of cell
cell motility
proteolysis
locomotion
reproductive process
reproduction
movement of cell or subcellular component
extracellular region
gene expression