PRTFDC1

Entrez Summary: N/A
UniProt Summary: Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

guanine biosynthetic process
hypoxanthine phosphoribosyltransferase activity
GMP catabolic process
guanine salvage
purine nucleobase salvage
guanosine-containing compound catabolic process
guanine metabolic process
purine ribonucleoside monophosphate catabolic process
ribonucleoside monophosphate catabolic process
purine ribonucleoside salvage
purine nucleoside monophosphate catabolic process
nucleoside monophosphate catabolic process
purine ribonucleoside catabolic process
purine nucleoside catabolic process
purine nucleobase biosynthetic process
GMP metabolic process
purine-containing compound salvage
nucleoside salvage
nucleobase biosynthetic process
purine nucleobase metabolic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
ribonucleoside catabolic process
purine nucleoside biosynthetic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
cellular metabolic compound salvage
nucleoside catabolic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside biosynthetic process
guanosine-containing compound metabolic process
nucleobase metabolic process
glycosyl compound biosynthetic process
purine nucleotide catabolic process
glycosyl compound catabolic process
pigment biosynthetic process
ribonucleoside monophosphate metabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process