PRTN3 [The Human Chemical-Genetic Interaction Map Project]

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======= PRTN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRTN3
  * **<color #00a2e8>Official Name</color>**: proteinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5657|5657]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24158|P24158]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRTN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRTN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/177020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1986|
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mature conventional dendritic cell differentiation|
|neutrophil extravasation|
|cell-cell junction maintenance|
|cell junction maintenance|
|negative regulation of phagocytosis|
|membrane protein ectodomain proteolysis|
|plasma membrane raft|
|dendritic cell differentiation|
|membrane protein proteolysis|
|cellular extravasation|
|collagen catabolic process|
|cellular component maintenance|
|serine-type peptidase activity|
|collagen metabolic process|
|azurophil granule lumen|
|neutrophil migration|
|regulation of phagocytosis|
|granulocyte migration|
|myeloid leukocyte differentiation|
|antimicrobial humoral response|
|myeloid leukocyte migration|
|cell-cell junction organization|
|serine-type endopeptidase activity|
|cell junction organization|
|myeloid cell differentiation|
|blood coagulation|
|coagulation|
|hemostasis|
|phagocytosis|
|leukocyte differentiation|
|signaling receptor binding|
|humoral immune response|
|enzyme binding|
|collagen-containing extracellular matrix|
|leukocyte migration|
|positive regulation of GTPase activity|
|wound healing|
|regulation of GTPase activity|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|response to wounding|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|cytokine-mediated signaling pathway|
|regulated exocytosis|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|exocytosis|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell migration|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|response to cytokine|
|secretion|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.81|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.85|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRTN3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>