PRTN3
Gene Information
- Official Symbol: PRTN3
- Official Name: proteinase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5657
- UniProt: P24158
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF1986 |
| Trypsin |
GO Terms
| mature conventional dendritic cell differentiation |
| neutrophil extravasation |
| cell-cell junction maintenance |
| cell junction maintenance |
| negative regulation of phagocytosis |
| membrane protein ectodomain proteolysis |
| plasma membrane raft |
| dendritic cell differentiation |
| membrane protein proteolysis |
| cellular extravasation |
| collagen catabolic process |
| cellular component maintenance |
| serine-type peptidase activity |
| collagen metabolic process |
| azurophil granule lumen |
| neutrophil migration |
| regulation of phagocytosis |
| granulocyte migration |
| myeloid leukocyte differentiation |
| antimicrobial humoral response |
| myeloid leukocyte migration |
| cell-cell junction organization |
| serine-type endopeptidase activity |
| cell junction organization |
| myeloid cell differentiation |
| blood coagulation |
| coagulation |
| hemostasis |
| phagocytosis |
| leukocyte differentiation |
| signaling receptor binding |
| humoral immune response |
| enzyme binding |
| collagen-containing extracellular matrix |
| leukocyte migration |
| positive regulation of GTPase activity |
| wound healing |
| regulation of GTPase activity |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of vesicle-mediated transport |
| hemopoiesis |
| response to wounding |
| myeloid leukocyte activation |
| hematopoietic or lymphoid organ development |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| immune system development |
| cytokine-mediated signaling pathway |
| regulated exocytosis |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| exocytosis |
| positive regulation of cell population proliferation |
| leukocyte activation |
| cell migration |
| secretion by cell |
| cellular response to cytokine stimulus |
| export from cell |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| response to cytokine |
| secretion |
| proteolysis |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| extracellular space |
| regulation of cell population proliferation |
| positive regulation of molecular function |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mubritinib 0.2μM R01 exp48 | 1.81 |
| Vinblastine 0.015μM R05 exp208 | 1.85 |
| Vinblastine 0.002μM R01 exp60 | 1.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11951
- Expression level (log2 read counts): -7.68
Expression Distribution
PRTN3 Expression in NALM6 Cells: -7.68
