PSMD10
Gene Information
- Official Symbol: PSMD10
- Official Name: proteasome 26S subunit, non-ATPase 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 5716
- UniProt: O75832
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011].
- UniProt Summary: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Pfam Domains GO Terms
Pfam Domains
| Ank 2 |
| Ank |
GO Terms
| proteasome regulatory particle assembly |
| cytoplasmic sequestering of NF-kappaB |
| proteasome regulatory particle, base subcomplex |
| proteasome assembly |
| negative regulation of DNA damage response, signal transduction by p53 class mediator |
| cytoplasmic sequestering of transcription factor |
| negative regulation of release of cytochrome c from mitochondria |
| cytoplasmic sequestering of protein |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of signal transduction by p53 class mediator |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cyclin-dependent protein kinase activity |
| intermediate filament cytoskeleton |
| regulation of release of cytochrome c from mitochondria |
| negative regulation of mitochondrion organization |
| proteasome complex |
| regulation of cellular amino acid metabolic process |
| regulation of hematopoietic stem cell differentiation |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| NIK/NF-kappaB signaling |
| regulation of cellular amine metabolic process |
| negative regulation of response to DNA damage stimulus |
| anaphase-promoting complex-dependent catabolic process |
| negative regulation of NF-kappaB transcription factor activity |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of G2/M transition of mitotic cell cycle |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| interleukin-1-mediated signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| antigen processing and presentation of peptide antigen via MHC class I |
| positive regulation of ubiquitin-dependent protein catabolic process |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of cell cycle G2/M phase transition |
| regulation of cyclin-dependent protein kinase activity |
| positive regulation of proteasomal protein catabolic process |
| maintenance of protein location |
| regulation of establishment of planar polarity |
| stimulatory C-type lectin receptor signaling pathway |
| positive regulation of protein ubiquitination |
| innate immune response activating cell surface receptor signaling pathway |
| regulation of stem cell differentiation |
| tumor necrosis factor-mediated signaling pathway |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| regulation of DNA-templated transcription in response to stress |
| non-canonical Wnt signaling pathway |
| positive regulation of protein modification by small protein conjugation or removal |
| positive regulation of cellular protein catabolic process |
| positive regulation of canonical Wnt signaling pathway |
| regulation of ubiquitin-dependent protein catabolic process |
| negative regulation of DNA-binding transcription factor activity |
| positive regulation of cell growth |
| maintenance of location |
| negative regulation of MAPK cascade |
| regulation of cellular ketone metabolic process |
| Fc-epsilon receptor signaling pathway |
| cellular response to interleukin-1 |
| negative regulation of canonical Wnt signaling pathway |
| T cell receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen |
| positive regulation of Wnt signaling pathway |
| regulation of mRNA stability |
| regulation of mitochondrion organization |
| regulation of morphogenesis of an epithelium |
| regulation of signal transduction by p53 class mediator |
| antigen processing and presentation of exogenous antigen |
| regulation of proteasomal protein catabolic process |
| regulation of RNA stability |
| cellular response to hypoxia |
| antigen processing and presentation of peptide antigen |
| regulation of G2/M transition of mitotic cell cycle |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| regulation of protein ubiquitination |
| regulation of mRNA catabolic process |
| negative regulation of Wnt signaling pathway |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to oxygen levels |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| antigen processing and presentation |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of cell cycle phase transition |
| innate immune response-activating signal transduction |
| cellular response to tumor necrosis factor |
| Fc receptor signaling pathway |
| regulation of cellular protein catabolic process |
| regulation of animal organ morphogenesis |
| activation of innate immune response |
| positive regulation of growth |
| response to tumor necrosis factor |
| protein deubiquitination |
| regulation of canonical Wnt signaling pathway |
| antigen receptor-mediated signaling pathway |
| protein modification by small protein removal |
| protein polyubiquitination |
| negative regulation of mitotic cell cycle |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| transcription factor binding |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of innate immune response |
| response to hypoxia |
| proteasomal protein catabolic process |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| regulation of Wnt signaling pathway |
| post-translational protein modification |
| positive regulation of response to biotic stimulus |
| positive regulation of cellular catabolic process |
| MAPK cascade |
| negative regulation of organelle organization |
| positive regulation of cell cycle |
| response to oxygen levels |
| regulation of protein catabolic process |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of cell growth |
| regulation of small molecule metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| positive regulation of protein kinase activity |
| modification-dependent macromolecule catabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| activation of immune response |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| regulation of growth |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| negative regulation of cellular component organization |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of cellular catabolic process |
| cellular protein-containing complex assembly |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| apoptotic process |
| protein phosphorylation |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| regulation of catabolic process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| programmed cell death |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 1/30 |
| central nervous system | 2/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 2/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 1/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17128
- Expression level (log2 read counts): 4.62
Expression Distribution
PSMD10 Expression in NALM6 Cells: 4.62
