PSPH [The Human Chemical-Genetic Interaction Map Project]

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======= PSPH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSPH
  * **<color #00a2e8>Official Name</color>**: phosphoserine phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5723|5723]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78330|P78330]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSPH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSPH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. {ECO:0000269|PubMed:12777757}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HAD|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoserine phosphatase activity|
|L-serine biosynthetic process|
|L-serine metabolic process|
|serine family amino acid biosynthetic process|
|response to testosterone|
|serine family amino acid metabolic process|
|phosphatase activity|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|response to ketone|
|alpha-amino acid metabolic process|
|response to mechanical stimulus|
|magnesium ion binding|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|dephosphorylation|
|cellular amino acid metabolic process|
|neuron projection|
|in utero embryonic development|
|response to nutrient levels|
|response to extracellular stimulus|
|small molecule biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|calcium ion binding|
|response to lipid|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|embryo development|
|oxoacid metabolic process|
|organic acid metabolic process|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.76|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.8|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.08|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.1|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.12|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.39|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.39|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.3|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSPH Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>