PSPH

Entrez Summary: The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. {ECO:0000269|PubMed:12777757}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HAD
Hydrolase

phosphoserine phosphatase activity
L-serine biosynthetic process
L-serine metabolic process
serine family amino acid biosynthetic process
response to testosterone
serine family amino acid metabolic process
phosphatase activity
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
response to ketone
alpha-amino acid metabolic process
response to mechanical stimulus
magnesium ion binding
carboxylic acid biosynthetic process
organic acid biosynthetic process
dephosphorylation
cellular amino acid metabolic process
neuron projection
in utero embryonic development
response to nutrient levels
response to extracellular stimulus
small molecule biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
calcium ion binding
response to lipid
protein homodimerization activity
carboxylic acid metabolic process
response to hormone
response to organic cyclic compound
embryo development
oxoacid metabolic process
organic acid metabolic process
response to abiotic stimulus
organonitrogen compound biosynthetic process
response to endogenous stimulus
response to oxygen-containing compound
small molecule metabolic process