PSRC1

Gene Information

Official Symbol: PSRC1
Official Name: proline and serine rich coiled-coil 1
Aliases and Previous Symbols: N/A
Entrez ID: 84722
UniProt: Q6PGN9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7000
Expression level (log2 read counts): 5.51

Expression Distribution

positive regulation of microtubule polymerization
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of microtubule polymerization or depolymerization
positive regulation of cyclin-dependent protein kinase activity
spindle microtubule
regulation of mitotic spindle organization
regulation of spindle organization
mitotic metaphase plate congression
regulation of microtubule polymerization
metaphase plate congression
establishment of chromosome localization
chromosome localization
regulation of microtubule polymerization or depolymerization
microtubule bundle formation
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
mitotic sister chromatid segregation
spindle
spindle pole
positive regulation of protein polymerization
sister chromatid segregation
mitotic nuclear division
microtubule cytoskeleton
midbody
negative regulation of cell growth
regulation of microtubule cytoskeleton organization
positive regulation of supramolecular fiber organization
nuclear chromosome segregation
positive regulation of cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
microtubule binding
negative regulation of growth
positive regulation of protein complex assembly
chromosome segregation
nuclear division
organelle fission
positive regulation of protein serine/threonine kinase activity
regulation of supramolecular fiber organization
establishment of organelle localization