PTAFR
Gene Information
- Official Symbol: PTAFR
- Official Name: platelet activating factor receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 5724
- UniProt: P25105
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
- UniProt Summary: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1374385, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| regulation of transcytosis |
| cellular response to gravity |
| positive regulation of transcytosis |
| regulation of maternal process involved in parturition |
| positive regulation of maternal process involved in parturition |
| response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine |
| cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine |
| regulation of voltage-gated chloride channel activity |
| positive regulation of voltage-gated chloride channel activity |
| platelet activating factor receptor activity |
| positive regulation of inorganic anion transmembrane transport |
| response to symbiotic bacterium |
| positive regulation of leukocyte tethering or rolling |
| positive regulation of neutrophil activation |
| positive regulation of neutrophil degranulation |
| response to symbiont |
| positive regulation of anion channel activity |
| lipopolysaccharide receptor activity |
| positive regulation of gastro-intestinal system smooth muscle contraction |
| regulation of gastro-intestinal system smooth muscle contraction |
| regulation of inorganic anion transmembrane transport |
| positive regulation of sensory perception of pain |
| positive regulation of anion transmembrane transport |
| regulation of neutrophil degranulation |
| regulation of leukocyte tethering or rolling |
| regulation of chloride transport |
| regulation of anion channel activity |
| response to gravity |
| regulation of neutrophil activation |
| G protein-coupled purinergic nucleotide receptor activity |
| G protein-coupled purinergic nucleotide receptor signaling pathway |
| positive regulation of leukocyte adhesion to vascular endothelial cell |
| positive regulation of inositol phosphate biosynthetic process |
| positive regulation of interleukin-6 biosynthetic process |
| inositol trisphosphate biosynthetic process |
| regulation of inositol phosphate biosynthetic process |
| parturition |
| positive regulation of cellular extravasation |
| transcytosis |
| inositol trisphosphate metabolic process |
| regulation of leukocyte adhesion to vascular endothelial cell |
| G protein-coupled purinergic receptor signaling pathway |
| purinergic nucleotide receptor signaling pathway |
| mitogen-activated protein kinase binding |
| regulation of interleukin-6 biosynthetic process |
| positive regulation of leukocyte degranulation |
| positive regulation of alcohol biosynthetic process |
| regulation of anion transmembrane transport |
| inositol phosphate biosynthetic process |
| purinergic receptor signaling pathway |
| regulation of cellular extravasation |
| positive regulation of vasoconstriction |
| positive regulation of myeloid leukocyte mediated immunity |
| positive regulation of smooth muscle contraction |
| lipopolysaccharide-mediated signaling pathway |
| lipopolysaccharide binding |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| response to dexamethasone |
| positive regulation of phospholipase C activity |
| negative regulation of blood pressure |
| positive regulation of muscle contraction |
| regulation of phospholipase C activity |
| regulation of leukocyte degranulation |
| positive regulation of anion transport |
| positive regulation of regulated secretory pathway |
| cellular response to cAMP |
| cellular response to fatty acid |
| positive regulation of blood vessel diameter |
| inositol phosphate metabolic process |
| regulation of vasoconstriction |
| positive regulation of cellular carbohydrate metabolic process |
| regulation of myeloid leukocyte mediated immunity |
| polyol biosynthetic process |
| positive regulation of phospholipase activity |
| regulation of smooth muscle contraction |
| positive regulation of nervous system process |
| positive regulation of cytokine biosynthetic process |
| positive regulation of blood circulation |
| phosphatidylinositol-mediated signaling |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| interferon-gamma-mediated signaling pathway |
| tertiary granule membrane |
| inositol lipid-mediated signaling |
| regulation of alcohol biosynthetic process |
| positive regulation of reproductive process |
| positive regulation of carbohydrate metabolic process |
| response to fatty acid |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of exocytosis |
| regulation of carbohydrate biosynthetic process |
| positive regulation of interleukin-6 production |
| response to antineoplastic agent |
| regulation of anion transport |
| regulation of lipase activity |
| secretory granule membrane |
| response to cAMP |
| positive regulation of ion transmembrane transporter activity |
| phospholipid binding |
| regulation of cytokine biosynthetic process |
| polyol metabolic process |
| positive regulation of transporter activity |
| alcohol biosynthetic process |
| positive regulation of translation |
| positive regulation of leukocyte migration |
| cellular response to ammonium ion |
| regulation of smooth muscle cell proliferation |
| positive regulation of leukocyte mediated immunity |
| response to organophosphorus |
| regulation of nervous system process |
| positive regulation of small molecule metabolic process |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of cellular carbohydrate metabolic process |
| regulation of interleukin-6 production |
| regulation of tube size |
| response to glucocorticoid |
| regulation of tumor necrosis factor production |
| cytokine production |
| positive regulation of cellular amide metabolic process |
| response to purine-containing compound |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of ion transmembrane transport |
| regulation of reproductive process |
| regulation of muscle contraction |
| response to corticosteroid |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| vascular process in circulatory system |
| regulation of blood pressure |
| response to interferon-gamma |
| cellular response to lipopolysaccharide |
| response to ammonium ion |
| organic hydroxy compound biosynthetic process |
| cellular response to molecule of bacterial origin |
| response to ketone |
| regulation of leukocyte migration |
| positive regulation of transmembrane transport |
| regulation of carbohydrate metabolic process |
| regulation of leukocyte mediated immunity |
| cellular response to acid chemical |
| multi-multicellular organism process |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of exocytosis |
| regulation of muscle system process |
| positive regulation of cell-cell adhesion |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of blood circulation |
| regulation of leukocyte cell-cell adhesion |
| response to xenobiotic stimulus |
| response to lipopolysaccharide |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| alcohol metabolic process |
| response to molecule of bacterial origin |
| response to steroid hormone |
| response to acid chemical |
| regulation of translation |
| blood circulation |
| circulatory system process |
| regulation of cell-cell adhesion |
| cellular response to drug |
| positive regulation of leukocyte activation |
| regulation of cellular amide metabolic process |
| positive regulation of cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of cell activation |
| regulation of small molecule metabolic process |
| positive regulation of secretion |
| positive regulation of cytokine production |
| organic hydroxy compound metabolic process |
| regulation of immune effector process |
| regulation of ion transmembrane transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| inflammatory response |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| regulation of anatomical structure size |
| myeloid leukocyte mediated immunity |
| cellular response to lipid |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| posttranscriptional regulation of gene expression |
| organophosphate biosynthetic process |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| regulation of system process |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| regulation of ion transport |
| regulated exocytosis |
| G protein-coupled receptor activity |
| regulation of secretion by cell |
| innate immune response |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| exocytosis |
| regulation of secretion |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| organophosphate metabolic process |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| leukocyte activation |
| defense response to other organism |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| multi-organism reproductive process |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| response to drug |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| response to cytokine |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| S-DABN 8μM R03 exp112 | -1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14003
- Expression level (log2 read counts): 2.83
Expression Distribution
PTAFR Expression in NALM6 Cells: 2.83
