PTCD1 [The Human Chemical-Genetic Interaction Map Project]

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======= PTCD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTCD1
  * **<color #00a2e8>Official Name</color>**: pentatricopeptide repeat domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26024|26024]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75127|O75127]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTCD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTCD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. {ECO:0000269|PubMed:21857155}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PPR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA 3-end processing|
|ncRNA 3-end processing|
|tRNA binding|
|tRNA processing|
|RNA 3-end processing|
|tRNA metabolic process|
|mitochondrial matrix|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.85|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.83|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.93|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.04|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.689|
|[[:human genes:q:qrsl1|QRSL1]]|0.468|
|[[:human genes:m:mtg2|MTG2]]|0.466|
|[[:human genes:l:lars2|LARS2]]|0.458|
|[[:human genes:m:mrpl21|MRPL21]]|0.455|
|[[:human genes:m:mrps14|MRPS14]]|0.451|
|[[:human genes:t:tars2|TARS2]]|0.449|
|[[:human genes:m:mrpl45|MRPL45]]|0.449|
|[[:human genes:f:ftsj2|FTSJ2]]|0.447|
|[[:human genes:y:yars2|YARS2]]|0.441|
|[[:human genes:m:mrpl23|MRPL23]]|0.439|
|[[:human genes:p:pars2|PARS2]]|0.439|
|[[:human genes:m:mtg1|MTG1]]|0.438|
|[[:human genes:s:selrc1|SELRC1]]|0.436|
|[[:human genes:m:malsu1|MALSU1]]|0.435|
|[[:human genes:m:mrpl47|MRPL47]]|0.433|
|[[:human genes:m:mrps21|MRPS21]]|0.431|
|[[:human genes:r:rpusd4|RPUSD4]]|0.431|
|[[:human genes:a:aars2|AARS2]]|0.43|
|[[:human genes:p:pet112|PET112]]|0.429|
|[[:human genes:c:coa3|COA3]]|0.429|
|[[:human genes:m:mrps34|MRPS34]]|0.428|
|[[:human genes:m:mrpl53|MRPL53]]|0.427|
|[[:human genes:m:mrps35|MRPS35]]|0.426|
|[[:human genes:i:ict1|ICT1]]|0.422|
|[[:human genes:n:nars2|NARS2]]|0.421|
|[[:human genes:e:ears2|EARS2]]|0.418|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.414|
|[[:human genes:m:mrps22|MRPS22]]|0.41|
|[[:human genes:c:cars2|CARS2]]|0.41|
|[[:human genes:n:ndufb2|NDUFB2]]|0.408|
|[[:human genes:m:mrps16|MRPS16]]|0.407|
|[[:human genes:g:gfm2|GFM2]]|0.407|
|[[:human genes:m:mrpl49|MRPL49]]|0.406|
|[[:human genes:n:ndufb11|NDUFB11]]|0.401|
|[[:human genes:m:mrpl12|MRPL12]]|0.401|
|[[:human genes:c:c17orf89|C17orf89]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTCD1 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>