PTCD1
Gene Information
- Official Symbol: PTCD1
- Official Name: pentatricopeptide repeat domain 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 26024
- UniProt: O75127
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015].
- UniProt Summary: Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. {ECO:0000269|PubMed:21857155}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1309
- Expression level (log2 read counts): 5.31
PTCD1 Expression in NALM6 Cells: 5.31
