PTGDS [The Human Chemical-Genetic Interaction Map Project]

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======= PTGDS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGDS
  * **<color #00a2e8>Official Name</color>**: prostaglandin D2 synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5730|5730]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41222|P41222]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGDS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGDS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176803|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. {ECO:0000269|PubMed:20667974, ECO:0000269|PubMed:9475419}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prostaglandin-D synthase activity|
|retinoid binding|
|cyclooxygenase pathway|
|regulation of circadian sleep/wake cycle, sleep|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|regulation of circadian sleep/wake cycle|
|fatty acid binding|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|arachidonic acid metabolic process|
|rough endoplasmic reticulum|
|regulation of behavior|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|regulation of circadian rhythm|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|fatty acid derivative metabolic process|
|monocarboxylic acid biosynthetic process|
|nuclear membrane|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|perinuclear region of cytoplasm|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|extracellular space|
|small molecule metabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGDS Expression in NALM6 Cells: -1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>