PTGDS

Entrez Summary: N/A
UniProt Summary: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. {ECO:0000269|PubMed:20667974, ECO:0000269|PubMed:9475419}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prostaglandin-D synthase activity
retinoid binding
cyclooxygenase pathway
regulation of circadian sleep/wake cycle, sleep
prostaglandin biosynthetic process
prostanoid biosynthetic process
regulation of circadian sleep/wake cycle
fatty acid binding
prostaglandin metabolic process
prostanoid metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
arachidonic acid metabolic process
rough endoplasmic reticulum
regulation of behavior
fatty acid derivative biosynthetic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
regulation of circadian rhythm
long-chain fatty acid metabolic process
fatty acid biosynthetic process
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
nuclear membrane
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
perinuclear region of cytoplasm
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
Golgi apparatus
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
extracellular space
small molecule metabolic process