PTGER3 [The Human Chemical-Genetic Interaction Map Project]

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======= PTGER3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGER3
  * **<color #00a2e8>Official Name</color>**: prostaglandin E receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5733|5733]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43115|P43115]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGER3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGER3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176806|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intestine smooth muscle contraction|
|prostaglandin E receptor activity|
|gastro-intestinal system smooth muscle contraction|
|negative regulation of gastric acid secretion|
|positive regulation of fever generation|
|regulation of fever generation|
|positive regulation of heat generation|
|regulation of gastric acid secretion|
|regulation of heat generation|
|phasic smooth muscle contraction|
|negative regulation of digestive system process|
|positive regulation of acute inflammatory response|
|regulation of digestive system process|
|regulation of acute inflammatory response|
|smooth muscle contraction|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of inflammatory response|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|nuclear envelope|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|muscle contraction|
|positive regulation of cytosolic calcium ion concentration|
|muscle system process|
|regulation of cytosolic calcium ion concentration|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|inflammatory response|
|cellular metal ion homeostasis|
|regulation of system process|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of defense response|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11736
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGER3 Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>