PTGER3

Gene Information

Official Symbol: PTGER3
Official Name: prostaglandin E receptor 3
Aliases and Previous Symbols: N/A
Entrez ID: 5733
UniProt: P43115
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11736
Expression level (log2 read counts): -2.35

Expression Distribution

intestine smooth muscle contraction
prostaglandin E receptor activity
gastro-intestinal system smooth muscle contraction
negative regulation of gastric acid secretion
positive regulation of fever generation
regulation of fever generation
positive regulation of heat generation
regulation of gastric acid secretion
regulation of heat generation
phasic smooth muscle contraction
negative regulation of digestive system process
positive regulation of acute inflammatory response
regulation of digestive system process
regulation of acute inflammatory response
smooth muscle contraction
phospholipase C-activating G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of inflammatory response
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
nuclear envelope
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
negative regulation of secretion
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
muscle contraction
positive regulation of cytosolic calcium ion concentration
muscle system process
regulation of cytosolic calcium ion concentration
regulation of inflammatory response
second-messenger-mediated signaling
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
positive regulation of defense response
negative regulation of transport
divalent inorganic cation homeostasis
inflammatory response
cellular metal ion homeostasis
regulation of system process
positive regulation of response to external stimulus