PTGS2
Gene Information
- Official Symbol: PTGS2
- Official Name: prostaglandin-endoperoxide synthase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5743
- UniProt: P35354
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
- UniProt Summary: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269|PubMed:16373578}.
Pfam Domains GO Terms
Pfam Domains
| An peroxidase |
GO Terms
| cellular response to non-ionic osmotic stress |
| response to non-ionic osmotic stress |
| maintenance of permeability of blood-brain barrier |
| prostaglandin-endoperoxide synthase activity |
| positive regulation of platelet-derived growth factor production |
| negative regulation of synaptic transmission, dopaminergic |
| regulation of platelet-derived growth factor production |
| cellular response to lead ion |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| positive regulation of fibroblast growth factor production |
| positive regulation of prostaglandin biosynthetic process |
| regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| positive regulation of fever generation |
| positive regulation of unsaturated fatty acid biosynthetic process |
| regulation of fever generation |
| regulation of fibroblast growth factor production |
| response to fructose |
| regulation of prostaglandin biosynthetic process |
| regulation of cellular response to osmotic stress |
| positive regulation of brown fat cell differentiation |
| positive regulation of synaptic plasticity |
| cyclooxygenase pathway |
| regulation of unsaturated fatty acid biosynthetic process |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| positive regulation of heat generation |
| regulation of response to osmotic stress |
| regulation of heat generation |
| NAD biosynthesis via nicotinamide riboside salvage pathway |
| negative regulation of smooth muscle contraction |
| lipoxygenase pathway |
| regulation of synaptic transmission, dopaminergic |
| regulation of brown fat cell differentiation |
| cellular response to fluid shear stress |
| cellular response to ATP |
| ovulation |
| response to manganese ion |
| positive regulation of fatty acid biosynthetic process |
| positive regulation of transforming growth factor beta production |
| prostanoid biosynthetic process |
| prostaglandin biosynthetic process |
| positive regulation of cell migration involved in sprouting angiogenesis |
| response to lithium ion |
| negative regulation of muscle contraction |
| response to lead ion |
| decidualization |
| response to angiotensin |
| brown fat cell differentiation |
| positive regulation of vascular endothelial growth factor production |
| positive regulation of acute inflammatory response |
| NAD biosynthetic process |
| response to vitamin D |
| long-chain fatty acid biosynthetic process |
| response to ATP |
| regulation of neuroinflammatory response |
| positive regulation of smooth muscle contraction |
| positive regulation of vasoconstriction |
| nicotinamide nucleotide biosynthetic process |
| regulation of vascular endothelial growth factor production |
| positive regulation of synaptic transmission, glutamatergic |
| pyridine nucleotide biosynthetic process |
| peroxidase activity |
| pyridine nucleotide metabolic process |
| nicotinamide nucleotide metabolic process |
| prostaglandin metabolic process |
| positive regulation of fatty acid metabolic process |
| prostanoid metabolic process |
| response to fluid shear stress |
| regulation of transforming growth factor beta production |
| cellular response to osmotic stress |
| maternal placenta development |
| pyridine-containing compound biosynthetic process |
| embryo implantation |
| positive regulation of protein import into nucleus |
| regulation of cell migration involved in sprouting angiogenesis |
| positive regulation of sprouting angiogenesis |
| positive regulation of protein import |
| positive regulation of nitric oxide biosynthetic process |
| negative regulation of blood vessel diameter |
| positive regulation of nitric oxide metabolic process |
| pyridine-containing compound metabolic process |
| unsaturated fatty acid biosynthetic process |
| regulation of acute inflammatory response |
| positive regulation of muscle contraction |
| regulation of fatty acid biosynthetic process |
| icosanoid biosynthetic process |
| bone mineralization |
| positive regulation of reactive oxygen species biosynthetic process |
| oxidoreduction coenzyme metabolic process |
| regulation of protein import into nucleus |
| positive regulation of blood vessel endothelial cell migration |
| regulation of nitric oxide biosynthetic process |
| arachidonic acid metabolic process |
| regulation of vasoconstriction |
| regulation of protein import |
| negative regulation of calcium ion transport |
| transferase activity |
| regulation of smooth muscle contraction |
| negative regulation of synaptic transmission |
| positive regulation of fat cell differentiation |
| positive regulation of nucleocytoplasmic transport |
| maternal process involved in female pregnancy |
| cellular response to nutrient |
| regulation of sprouting angiogenesis |
| regulation of synaptic transmission, glutamatergic |
| cellular response to heat |
| positive regulation of blood circulation |
| sensory perception of pain |
| caveola |
| positive regulation of protein localization to nucleus |
| response to osmotic stress |
| positive regulation of lipid biosynthetic process |
| cellular response to mechanical stimulus |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to UV |
| response to fatty acid |
| regulation of reactive oxygen species biosynthetic process |
| positive regulation of smooth muscle cell proliferation |
| response to vitamin |
| regulation of fatty acid metabolic process |
| regulation of blood vessel endothelial cell migration |
| negative regulation of cysteine-type endopeptidase activity |
| cellular oxidant detoxification |
| hair cycle |
| molting cycle |
| fatty acid derivative biosynthetic process |
| biomineral tissue development |
| biomineralization |
| positive regulation of reactive oxygen species metabolic process |
| negative regulation of intrinsic apoptotic signaling pathway |
| positive regulation of endothelial cell migration |
| cellular detoxification |
| positive regulation of peptidyl-serine phosphorylation |
| fat cell differentiation |
| regulation of nucleocytoplasmic transport |
| unsaturated fatty acid metabolic process |
| response to heat |
| icosanoid metabolic process |
| cellular response to light stimulus |
| long-chain fatty acid metabolic process |
| regulation of protein localization to nucleus |
| memory |
| fatty acid biosynthetic process |
| regulation of fat cell differentiation |
| detoxification |
| female gamete generation |
| regulation of smooth muscle cell proliferation |
| response to estradiol |
| response to organophosphorus |
| regulation of peptidyl-serine phosphorylation |
| coenzyme biosynthetic process |
| positive regulation of small molecule metabolic process |
| regulation of blood vessel diameter |
| positive regulation of inflammatory response |
| regulation of tube diameter |
| regulation of tube size |
| positive regulation of epithelial cell migration |
| heme binding |
| positive regulation of lipid metabolic process |
| response to UV |
| response to hexose |
| response to glucocorticoid |
| learning |
| negative regulation of ion transport |
| response to monosaccharide |
| cytokine production |
| positive regulation of synaptic transmission |
| response to purine-containing compound |
| placenta development |
| positive regulation of intracellular protein transport |
| regulation of endothelial cell migration |
| regulation of muscle contraction |
| regulation of intrinsic apoptotic signaling pathway |
| response to corticosteroid |
| positive regulation of angiogenesis |
| fatty acid derivative metabolic process |
| vascular process in circulatory system |
| response to carbohydrate |
| regulation of cellular ketone metabolic process |
| cellular response to radiation |
| response to temperature stimulus |
| regulation of reactive oxygen species metabolic process |
| female pregnancy |
| regulation of blood pressure |
| positive regulation of vasculature development |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| cellular response to hypoxia |
| regulation of synaptic plasticity |
| cellular response to metal ion |
| cellular response to decreased oxygen levels |
| positive regulation of intracellular transport |
| multi-multicellular organism process |
| cofactor biosynthetic process |
| response to mechanical stimulus |
| cellular response to toxic substance |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| response to nutrient |
| cellular response to oxygen levels |
| regulation of epithelial cell migration |
| cellular response to inorganic substance |
| negative regulation of apoptotic signaling pathway |
| regulation of intracellular protein transport |
| cellular response to nutrient levels |
| regulation of muscle system process |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| regulation of calcium ion transport |
| coenzyme metabolic process |
| negative regulation of peptidase activity |
| learning or memory |
| ossification |
| response to tumor necrosis factor |
| cellular response to extracellular stimulus |
| aging |
| regulation of angiogenesis |
| regulation of blood circulation |
| cognition |
| carboxylic acid biosynthetic process |
| endoplasmic reticulum lumen |
| organic acid biosynthetic process |
| response to light stimulus |
| response to lipopolysaccharide |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| angiogenesis |
| regulation of vasculature development |
| neuron projection |
| fatty acid metabolic process |
| positive regulation of cellular protein localization |
| response to molecule of bacterial origin |
| response to steroid hormone |
| cellular response to external stimulus |
| regulation of inflammatory response |
| response to hypoxia |
| response to acid chemical |
| enzyme binding |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| negative regulation of proteolysis |
| response to decreased oxygen levels |
| response to metal ion |
| response to oxygen levels |
| regulation of metal ion transport |
| response to oxidative stress |
| blood circulation |
| response to peptide hormone |
| regulation of lipid metabolic process |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| blood vessel morphogenesis |
| regulation of endopeptidase activity |
| reproductive structure development |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| reproductive system development |
| cofactor metabolic process |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| nucleotide metabolic process |
| positive regulation of cytokine production |
| nucleoside phosphate metabolic process |
| negative regulation of hydrolase activity |
| positive regulation of establishment of protein localization |
| response to peptide |
| positive regulation of defense response |
| negative regulation of transport |
| blood vessel development |
| inflammatory response |
| response to nutrient levels |
| positive regulation of cell migration |
| response to toxic substance |
| negative regulation of intracellular signal transduction |
| vasculature development |
| regulation of anatomical structure size |
| cardiovascular system development |
| positive regulation of cell motility |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| response to inorganic substance |
| organophosphate biosynthetic process |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| positive regulation of locomotion |
| behavior |
| negative regulation of cell cycle |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| regulation of system process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| response to bacterium |
| gamete generation |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of defense response |
| negative regulation of catalytic activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| response to lipid |
| circulatory system development |
| protein homodimerization activity |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| carboxylic acid metabolic process |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| positive regulation of cell differentiation |
| sensory perception |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| negative regulation of cell death |
| multi-organism reproductive process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| response to drug |
| organic acid metabolic process |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13728
- Expression level (log2 read counts): -4.14
Expression Distribution
PTGS2 Expression in NALM6 Cells: -4.14
