PTH2
Gene Information
- Official Symbol: PTH2
- Official Name: parathyroid hormone 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 113091
- UniProt: Q96A98
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269|PubMed:11861531, ECO:0000269|PubMed:12559132, ECO:0000269|PubMed:12754053, ECO:0000269|PubMed:14988434}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5586
- Expression level (log2 read counts): -3.13