PTN

Gene Information

Official Symbol: PTN
Official Name: pleiotrophin
Aliases and Previous Symbols: N/A
Entrez ID: 5764
UniProt: P21246
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777). {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:16814777, ECO:0000269|PubMed:1768439, ECO:0000269|PubMed:26896299}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13559
Expression level (log2 read counts): -4.6

Expression Distribution

rod bipolar cell differentiation
response to kainic acid
response to ciliary neurotrophic factor
dendrite regeneration
negative regulation of neuromuscular junction development
positive regulation of skeletal muscle acetylcholine-gated channel clustering
retinal rod cell differentiation
chondroitin sulfate proteoglycan binding
heparan sulfate binding
positive regulation of postsynaptic membrane organization
ossification involved in bone remodeling
retinal bipolar neuron differentiation
leukocyte chemotaxis involved in inflammatory response
regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of neuromuscular junction development
transmembrane receptor protein tyrosine phosphatase signaling pathway
positive regulation of receptor clustering
dendrite arborization
vascular endothelial growth factor binding
syndecan binding
negative regulation of neuroblast proliferation
positive regulation of hepatocyte proliferation
negative regulation of mesenchymal cell proliferation
positive regulation of axon regeneration
positive regulation of neuron projection regeneration
chondroitin sulfate binding
regulation of neuromuscular junction development
neuron projection arborization
negative regulation of long-term synaptic potentiation
regulation of receptor clustering
thalamus development
negative regulation of stem cell proliferation
negative regulation of membrane potential
leukocyte migration involved in inflammatory response
regulation of hepatocyte proliferation
negative regulation of glial cell proliferation
regulation of postsynaptic membrane organization
cellular response to vitamin D
estrous cycle
camera-type eye photoreceptor cell differentiation