PTPLAD1

Gene Information

Official Symbol: HACD3
Official Name: 3-hydroxyacyl-CoA dehydratase 3
Aliases and Previous Symbols: N/A
Entrez ID: 51495
UniProt: Q9P035
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506, ECO:0000269|PubMed:25687571}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15347
Expression level (log2 read counts): 7.62

Expression Distribution

Screen	Score
Cisplatin 0.35μM R06 exp273	-2.12
ABT-702 5μM R06 exp261	-1.78
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.96

CS
PTPLA

positive regulation by virus of viral protein levels in host cell
3-hydroxy-arachidoyl-CoA dehydratase activity
3-hydroxy-behenoyl-CoA dehydratase activity
3-hydroxy-lignoceroyl-CoA dehydratase activity
very-long-chain 3-hydroxyacyl-CoA dehydratase activity
3-hydroxyacyl-CoA dehydratase activity
regulation by virus of viral protein levels in host cell
very long-chain fatty acid biosynthetic process
fatty acid elongation
Rac protein signal transduction
very long-chain fatty acid metabolic process
positive regulation of viral genome replication
activation of JUN kinase activity
positive regulation of viral life cycle
I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
Rho protein signal transduction
JNK cascade
regulation of JUN kinase activity
sphingolipid biosynthetic process
regulation of viral genome replication
stress-activated MAPK cascade
positive regulation of viral process
fatty acid biosynthetic process
membrane lipid biosynthetic process
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
regulation of viral life cycle
sphingolipid metabolic process
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
monocarboxylic acid biosynthetic process
regulation of JNK cascade
membrane lipid metabolic process
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
nuclear membrane